Pernicious anaemia,Vitamin B12 Without Needles – Subcutaneously or Intramuscular

Needleless injecting of Vitamin B12 coenzyme (methylcobalamin) or methyl-B12, is a very popular use for the Comfort-in™ jet injector system, particularly because they reduce pain and anxiety.

The Comfort-in™ needle-free injection system is an excellent alternative to needle-based syringes and is an effective and convenient method for B12 needle-free delivery.

Intramuscular vs Subcutaneous

Parenteral administration of vitamin B-12 via injection has been standard protocol for decades, according to the Centers for Disease Control and Prevention. Both types of injections have few associated side effects and constitute very effective treatment. Patients report less burning with a subcutaneous administration, which gives it a slight advantage over an intramuscular injection, according to the CDC.


People with dietary restrictions, such as vegans or vegetarians, use methyl B12 injections to supplement diets lacking in sufficient vitamin B12.

Another common use for methyl B12 is in children with autism spectrum disorders and dyslexia and often involves injecting methyl-B12 into subcutaneous fat, allowing for slow and sustained release from the tissue.

The Comfort-in™ jet injection system allows injection of methyl-B12 without needles, making ‘injection time’ a much simpler and relaxed experience for both parent and child.

Vitamin B12 injections are also used by people with impaired vitamin B12 absorption or deficiency called Pernicious anaemia caused by:

  • Inadequate dietary intake of B12
  • Loss of gastric parietal cells in chronic atrophic gastritis
  • Structural damage or surgical resection of the small intestine or stomach
  • Long-term use of acid regulating medication
  • Alcoholism
  • Gastric banding surgery
  • Celiac’s disease
  • Pernicious anaemia
  • Crohn’s disease

Until now, injection of methyl-B12 has required a needle. However, needles and syringes can be a cause of concern for many people, especially if needing to be self-administered or administered to a loved one.

Jet injection is a virtually painless and comfortable method of injecting methyl-B12 without needles and can be used with adults, children and pets.


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